The STEP Study Provides a Hint That Vaccine Induction of the Right CD8 1 T Cell Responses Can Facilitate Immune Control of HIV

Estimados colegas , este es un estudio interesante vale la pena leerlo.

Saludos 

Dr. Carlos Erazo

The STEP study was a large, randomized, placebo-controlled, test-of-concept vaccine trial using an Ad5 vector expressing human immunodeficiency virus (HIV)–1 Gag, Pol, and Nef designed to induce T cell immunity to HIV-1. This trial was stopped and unblinded in 2007 after an interim analysis showed that the vaccine did not achieve efficacy for the 2 primary study end points, HIV-1 acquisition and plasma HIV-1 RNA levels 3 months after diagnosis of HIV-1 infection, and suggested that vaccinated individuals with high preexisting antibody titers against Ad5 might be at a higher risk of acquiring HIV-1 infection [1–2]. These results initiated reconsideration in the HIV-1 research field of the role of T cells in protection from HIV-1 infection and disease progression.

http://jid.oxfordjournals.org/content/203/6/753.full.pdf+html